MuscleHell

Quoted from "Mex1"

Also, nur, dass ich das in dem ersten Video richtig verstanden habe:
Creatin soll man nur zu sich nehmen, wenn es komplett aufgelöst ist? Löst sich das denn nicht auch im Körper?
Weil ich nehm einfach immer nur den Löffel in den Mund und spül dann mit Wasser runter...
Wäre sehr nett, wenn jemand dazu eine Antwort hat.

Quoted from "Mex1"

1. Creatin löst sich in warmen Wasser deutlich schneller.

Quoted from "Mex1"

2. Creapure löst sich schneller als normales CreaMono.

Quoted from "Mex1"

9. Creatin ist deutlich stabiler als die meisten Leute denken, wieder ein erfundenes Problem der Supp-Industrie. Stabil über viele Stunden (größtenteils), aber natürlich nicht monate- bzw. jahrelang!

Quoted from "Mex1"

10. Sehr vereinfacht zusammengefasst: Die meisten anderen Formen bringen dem normalen Verbraucher nichts.

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Abstract

Numerous creatine formulations have been developed primarily to maximize creatine absorption. Creatine ethyl ester is alleged to increase creatine bio-availability. This study examined how a seven-week supplementation regimen combined with resistance training affected body composition, muscle mass, muscle strength and power, serum and muscle creatine levels, and serum creatinine levels in 30 non-resistance-trained males. In a double-blind manner, participants were randomly assigned to a maltodextrose placebo (PLA), creatine monohydrate (CRT), or creatine ethyl ester (CEE) group. The supplements were orally ingested at a dose of 0.30 g/kg fat-free body mass (approximately 20 g/day) for five days followed by ingestion at 0.075 g/kg fat free mass (approximately 5 g/day) for 42 days.

Serum creatinine

A significant difference over the course of the four testing sessions (p = 0.001) and significant difference between groups (p = 0.001) was observed for serum creatinine. Serum creatinine was greater in the CEE group compared to the PLA (p = 0.001) and CRT (p = 0.001) groups. Further analysis revealed significant elevations in serum creatinine with the CEE group that occurred days 6 (p = 0.007), 27 (p = 0.005), and 48 (p = 0.005) (Figure 3).

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# Breakdown to Creatinine
CEE is hydrolysed to the breakdown product creatinine after it has been absorbed from the digestive system. Child & Tallon (2004) studied the conversion of creatine to creatinine in the stomach. They compared three commercial creatine products during degradation in acidic solutions in order to mimic the stomach conditions. Creatine availability was assessed by immediately assaying for free creatine, CEE and creatinine. After 30 minutes incubation only 62-73% of the initial CEE was left from the CEE products, whereas more than 99% of the creatine remained available from the monohydrate product. These reductions in CEE availability were accompanied by substantial creatinine formation, without the appearance of free creatine. After 120 minutes there had been even further degredation of the CEE, while more than 99% of the creatine remained available from monohydrate.

CEE is claimed to provide several advantages over creatine monohydrate because of increased solubility and stability. However it appears that the addition of the ethyl group to creatine actually reduces acid stability and accelerates its breakdown to creatinine. This substantially reduces creatine availability in its esterified form and as a consequence CEE is inferior to creatine monohydrate as a source of free creatine.

CEE offers no advantage over creatine monohydrate which has a bioavailability of nearly 100%, i.e. nearly all is absorbed. Infact if hydrolysis of CEE is less than 99% then it must be inferior to monohydrate, and in the case of hydrolysis there are no circumstances in which it could be better than the monohydrate in increasing tissue creatine levels.

Quoted from "infraspinatus"

ich pers. habe gute erfahrungen mit tcm, -phosphaten und -citraten gemacht.

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If you have problems with CM, malate, citrate, gluconate, and Mg forms might be worth trying. They will cost a bit more, but at worst, should be equal in effect to CM. Unlike CEE, and some others in the graveyard list, they are not likely to be any worse then CM in terms of conversion to creatinine, etc.

Quoted from "infraspinatus"

meine devise: mit cm beginnen ... gute ergebnisse ... bei cm bleiben ... ansonsten im dedizierten rahmen experimentieren ...

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Poor solubility is a well known factor for decreasing the absorption of various compounds, and making the compound soluble greatly improves absorption and reduces GI problems. For example:

Methods Find Exp Clin Pharmacol 1998, 20(3): 211

Micronization: A method of improving the bioavailability of poorly soluble drugs Chaumeil, J.C.

For poorly soluble drugs, the digestive absorption depends on their rate of dissolution. Decreasing the particle size of these drugs improves their rate of dissolution. Fine grinding mills are use to micronize powders: either jar mills or fluid energy mills. These processes were applied to griseofulvin, progesterone, spironolactone and diosmin. For each drug, micronization improved their digestive absorption, and consequently their bioavailability and clinical efficacy.

Hence, why I recommend and use micronized CM...

Dr. John Berardi has made a few comments that sum it up well:

"Since creatine is very hard to dissolve in regular room temperature beverages, researchers had been giving creatine in warm coffee and tea to ensure dissolution of the powder and to mask the taste. Also this dissolution makes taking creatine orally easier on subjects and their digestive systems."

" when the creatine gets to your gastrointestinal tract, the body tries to solubilize it. Why? Because nutrients cannot be absorbed if not solubilized or dissolved in a solution. They will just sit around in the pit of your stomach in powder form and eventually pass right out of you. So what the body does to remedy this is to suck fluids out of the cells of the digestive organs in order to provide enough fluid to dissolve the creatine. But what then happens is that all this fluid that's sucked into the GI tract needs to quickly be eliminated and this leads to diarrhea. So in solubilizing your creatine, the GI causes some nasty bathroom situations. Not to mention the fact that a lot of the creatine is lost during such porcelain episodes."

I assume he's referring more to the loading phases I suspect that few people bother with anymore as far as "porcelain episodes" is concerned, but the fact is, best results will be had is you fully dissolve the creatine first.